Tomonaga-Luttinger liquid correlations and Fabry-Perot interference in conductance and finite-frequency shot noise in a single-walled carbon nanotube

We present a detailed theoretical investigation of transport through a single-walled carbon nanotube (SWNT) in good contact to metal leads where weak backscattering at the interfaces between SWNT and source and drain reservoirs gives rise to electronic Fabry-Perot (FP) oscillations in conductance and shot noise. We include the electron-electron interaction and the finite length of the SWNT within the inhomogeneous Tomonaga-Luttinger liquid (TLL) model and treat the non-equilibrium effects due to an applied bias voltage within the Keldysh approach. In low-frequency transport properties, the TLL effect is apparent mainly via power-law characteristics as a function of bias voltage or temperature at energy scales above the finite level spacing of the SWNT. The FP-frequency is dominated by the non-interacting spin mode velocity due to two degenerate subbands rather than the interacting charge velocity. At higher frequencies, the excess noise is shown to be capable of resolving the splintering of the transported electrons arising from the mismatch of the TLL-parameter at the interface between metal reservoirs and SWNT. This dynamics leads to a periodic shot noise suppression as a function of frequency and with a period that is determined solely by the charge velocity. At large bias voltages, these oscillations are dominant over the ordinary FP-oscillations caused by two weak backscatterers. This makes shot noise an invaluable tool to distinguish the two mode velocities in the SWNT.Comment: 20 pages, 9 figure

Facilitation of I Kr current by some hERG channel blockers suppresses early afterdepolarizations.

Drug-induced block of the cardiac rapid delayed rectifying potassium current (I Kr), carried by the human ether-a-go-go-related gene (hERG) channel, is the most common cause of acquired long QT syndrome. Indeed, some, but not all, drugs that block hERG channels cause fatal cardiac arrhythmias. However, there is no clear method to distinguish between drugs that cause deadly arrhythmias and those that are clinically safe. Here we propose a mechanism that could explain why certain clinically used hERG blockers are less proarrhythmic than others. We demonstrate that several drugs that block hERG channels, but have favorable cardiac safety profiles, also evoke another effect; they facilitate the hERG current amplitude in response to low-voltage depolarization. To investigate how hERG facilitation impacts cardiac safety, we develop computational models of I Kr block with and without this facilitation. We constrain the models using data from voltage clamp recordings of hERG block and facilitation by nifekalant, a safe class III antiarrhythmic agent. Human ventricular action potential simulations demonstrate the ability of nifekalant to suppress ectopic excitations, with or without facilitation. Without facilitation, excessive I Kr block evokes early afterdepolarizations, which cause lethal arrhythmias. When facilitation is introduced, early afterdepolarizations are prevented at the same degree of block. Facilitation appears to prevent early afterdepolarizations by increasing I Kr during the repolarization phase of action potentials. We empirically test this prediction in isolated rabbit ventricular myocytes and find that action potential prolongation with nifekalant is less likely to induce early afterdepolarization than action potential prolongation with dofetilide, a hERG channel blocker that does not induce facilitation. Our data suggest that hERG channel blockers that induce facilitation increase the repolarization reserve of cardiac myocytes, rendering them less likely to trigger lethal ventricular arrhythmias

Induced metamorphosis in crustacean y-larvae: Towards a solution to a 100-year-old riddle

<p>Abstract</p> <p>Background</p> <p>The y-larva, a crustacean larval type first identified more than 100 years ago, has been found in marine plankton samples collected in the arctic, temperate and tropical regions of all oceans. The great species diversity found among y-larvae (we have identified more than 40 species at our study site alone) indicates that the adult organism may play a significant ecological role. However, despite intense efforts, the adult y-organism has never been identified, and nothing is therefore known about its biology.</p> <p>Results</p> <p>We have successfully and repeatedly induced metamorphosis of y-larvae into a novel, highly reduced juvenile stage by applying the crustacean molting hormone 20-HE. The new stage is slug-like, unsegmented and lacks both limbs and almost all other traits normally characterizing arthropods, but it is capable of vigorous peristaltic motions.</p> <p>Conclusion</p> <p>From our observations on live and preserved material we conclude that adult Facetotecta are endoparasitic in still to be identified marine hosts and with a juvenile stage that represents a remarkable convergence to that seen in parasitic barnacles (Crustacea Cirripedia Rhizocephala). From the distribution and abundance of facetotectan y-larvae in the world's oceans we furthermore suggest that these parasites are widespread and could play an important role in the marine environment.</p

Scaling Behavior of Ricci Curvature at Short Distance near Two Dimensions

We study the renormalization of the Ricci curvature as an example of generally covariant operators in quantum gravity near two dimensions. We find that it scales with a definite scaling dimension at short distance. The Ricci curvature singularity at the big bang can be viewed as such a scaling phenomenon. The problem of the spacetime singularity may be resolved by the scale invariance of the spacetime at short distance.Comment: 9pages, LaTe

Structural Plasticity within the Postsynaptic Density

The postsynaptic density (PSD) is a large protein complex that clusters neurotransmitter receptors at the synapse and organizes the intracellular signaling molecules responsible for altering the efficiency of synaptic transmission – termed synaptic plasticity. We propose that synapses from different parts of the brain place unique demands on the process of synaptic transmission and that the structure and composition of the PSD play a role in providing these distinctive properties. To begin to address this question, PSDs were isolated from adult rat cerebella, hippocampi and cortices, three brain areas amenable to straightforward isolation that contain unique distributions of neuronal cell types. Electron-tomography (ET) was used to visualize the fine morphology of the isolated PSDs and calculate total protein occupancy within the PSD structure. Immunogold labeling was utilized to quantify protein composition and distribution of key signaling and scaffold molecules. Although the mean surface area did not significantly differ between PSD types, the PSD thickness, as measured from Cryo ET reconstructions, differed significantly between PSD types. Labeling densities for PSD-95 and αCaMKII were found to differ dramatically among the PSD types, while all regions had moderate to high labeling for βCaMKII, illustrating the importance of βCaMKII to the PSD structure. PSD-95, a scaffold protein, was absent from a fraction of cerebellar PSDs, unlike hippocampal and cortical PSDs, showing that protein composition varies between PSD types. Ripley's K function analysis of immunogold labeled PSDs showed that PSD-95 was clustered in cerebellar PSDs, unlike other PSD types, suggesting a different function for PSD-95 in cerebellar PSDs. In contrast, βCaMKII was found to have similar non-random organization in all PSD types. These results support the idea that the composition and structure of the PSD are modified to achieve the specific synaptic functions required of each brain region

Altered actin centripetal retrograde flow in physically restricted immunological synapses

Antigen recognition by T cells involves large scale spatial reorganization of numerous receptor, adhesion, and costimulatory proteins within the T cell-antigen presenting cell (APC) junction. The resulting patterns can be distinctive, and are collectively known as the immunological synapse. Dynamical assembly of cytoskeletal network is believed to play an important role in driving these assembly processes. In one experimental strategy, the APC is replaced with a synthetic supported membrane. An advantage of this configuration is that solid structures patterned onto the underlying substrate can guide immunological synapse assembly into altered patterns. Here, we use mobile anti-CD3ε on the spatial-partitioned supported bilayer to ligate and trigger T cell receptor (TCR) in live Jurkat T cells. Simultaneous tracking of both TCR clusters and GFP-actin speckles reveals their dynamic association and individual flow patterns. Actin retrograde flow directs the inward transport of TCR clusters. Flow-based particle tracking algorithms allow us to investigate the velocity distribution of actin flow field across the whole synapse, and centripetal velocity of actin flow decreases as it moves toward the center of synapse. Localized actin flow analysis reveals that, while there is no influence on actin motion from substrate patterns directly, velocity differences of actin are observed over physically trapped TCR clusters. Actin flow regains its velocity immediately after passing through confined TCR clusters. These observations are consistent with a dynamic and dissipative coupling between TCR clusters and viscoelastic actin network. © 2010 Yu et al.published_or_final_versio

A molecular dynamics simulation of polymer crystallization from oriented amorphous state

Molecular process of crystallization from an oriented amorphous state was reproduced by molecular dynamics simulation for a realistic polyethylene model. Initial oriented amorphous state was obtained by uniaxial drawing an isotropic glassy state at 100 K. By the temperature jump from 100 K to 330 K, there occurred the crystallization into the fiber structure, during the process of which we observed the developments of various order parameters. The real space image and its Fourier transform revealed that a hexagonally ordered domain was initially formed, and then highly ordered crystalline state with stacked lamellae developed after further adjustment of the relative heights of the chains along their axes.Comment: 4 pages, 3 figure

Quantum Bit Regeneration

Decoherence and loss will limit the practicality of quantum cryptography and computing unless successful error correction techniques are developed. To this end, we have discovered a new scheme for perfectly detecting and rejecting the error caused by loss (amplitude damping to a reservoir at T=0), based on using a dual-rail representation of a quantum bit. This is possible because (1) balanced loss does not perform a ``which-path'' measurement in an interferometer, and (2) balanced quantum nondemolition measurement of the ``total'' photon number can be used to detect loss-induced quantum jumps without disturbing the quantum coherence essential to the quantum bit. Our results are immediately applicable to optical quantum computers using single photonics devices.Comment: 4 pages, postscript only, figures available at http://feynman.stanford.edu/qcom

Time-resolved spectroscopy of multi-excitonic decay in an InAs quantum dot

The multi-excitonic decay process in a single InAs quantum dot is studied through high-resolution time-resolved spectroscopy. A cascaded emission sequence involving three spectral lines is seen that is described well over a wide range of pump powers by a simple model. The measured biexcitonic decay rate is about 1.5 times the single-exciton decay rate. This ratio suggests the presence of selection rules, as well as a significant effect of the Coulomb interaction on the biexcitonic wavefunction.Comment: one typo fixe

Simulating chemistry efficiently on fault-tolerant quantum computers

Quantum computers can in principle simulate quantum physics exponentially faster than their classical counterparts, but some technical hurdles remain. Here we consider methods to make proposed chemical simulation algorithms computationally fast on fault-tolerant quantum computers in the circuit model. Fault tolerance constrains the choice of available gates, so that arbitrary gates required for a simulation algorithm must be constructed from sequences of fundamental operations. We examine techniques for constructing arbitrary gates which perform substantially faster than circuits based on the conventional Solovay-Kitaev algorithm [C.M. Dawson and M.A. Nielsen, \emph{Quantum Inf. Comput.}, \textbf{6}:81, 2006]. For a given approximation error $\epsilon$, arbitrary single-qubit gates can be produced fault-tolerantly and using a limited set of gates in time which is $O(\log \epsilon)$ or $O(\log \log \epsilon)$; with sufficient parallel preparation of ancillas, constant average depth is possible using a method we call programmable ancilla rotations. Moreover, we construct and analyze efficient implementations of first- and second-quantized simulation algorithms using the fault-tolerant arbitrary gates and other techniques, such as implementing various subroutines in constant time. A specific example we analyze is the ground-state energy calculation for Lithium hydride.Comment: 33 pages, 18 figure